NA-245 Karachi West-II () is a constituency for the National Assembly of Pakistan.
The constituency includes Orangi Town area of Karachi West District.
Data Nagar, Qatar Mor, Sector 1,6,7,8, Kati Pahari, Iqbal Goth Baloch Goth, Pakhtun Abad, New Mianwali Colony, Manghopir (partly)
General elections were held on 10 October 2002. Sarkaruddin Advocate of Muttahida Qaumi Movement won by 30,408 votes.
General elections were held on 18 February 2008. Khuwaja Sohail Mansoor of Muttahida Qaumi Movement won by 67,799 votes.
General elections were held on 11 May 2013. Khuwaja Sohail Mansoor of Muttahida Qaumi Movement won by 87,805 votes and became the member of National Assembly.
General elections were held on 25 July 2018.
General elections were held on 8 February 2024. Syed Hafeezuddin won the election with 57,356 votes.