Comabbio is a comune (municipality) in the Province of Varese in the Italian region Lombardy, located about northwest of Milan and about southwest of Varese. On 31 December 2004, it had a population of 1,025 and an area of .
Comabbio borders the following municipalities: Mercallo, Osmate, Sesto Calende, Ternate, Travedona-Monate, Varano Borghi, Vergiate.