The Colorado River Headwaters National Scenic Byway is an National Scenic Byway and Colorado Scenic and Historic Byway located in Eagle and Grand counties, Colorado, US. The byway follows the upper Colorado River from Grand Lake down to State Bridge. The byway connects with the Trail Ridge Road/Beaver Meadow National Scenic Byway at Grand Lake.
In 2018 USA Today named it as one of the best waterside drives in the country.