Colle Santa Lucia (; Ladin language: Col) is a comune (municipality) in the Province of Belluno in the Italian region of Veneto, located about north of Venice and about northwest of Belluno. As of 31 December 2004, it had a population of 408 and an area of . The population speaks a Venetian dialect called Ladin Venetian that is heavily influenced by the Ladin language.
Colle Santa Lucia borders the following municipalities: Alleghe, Cortina d'Ampezzo, Livinallongo del Col di Lana, Rocca Pietore, San Vito di Cadore, Selva di Cadore.