Coldwater Creek is a stream in Miami County, Kansas and Cass County, Missouri in the United States. It is a tributary of the South Fork of the South Grand River.
The stream headwaters arise in eastern Kansas just over one mile west of the Kansas-Missouri border at and it flows east into Missouri and crosses under Missouri Route D just south of Lisle. Its confluence with the South Fork is at at an elevation of 860 feet.
Coldwater Creek was so named due to the cold water it carries.