Col. Edward Cook House is a historic home located at Washington Township, Fayette County, Pennsylvania, USA. It was built between 1772 and 1776, and is a two-story, four-bay, rectangular stone dwelling with a one-story kitchen wing. The main block measures 36 feet by 28 feet and the kitchen wing 24 feet by 20 feet. It has a medium-pitched gable roof and plain cornice with return. Also on the property are a contributing smoke house and wash house.
It was added to the National Register of Historic Places in 1978.