Clifton is a Census-designated place located in Spartanburg County in the U.S. State of South Carolina. According to the 2010 United States census, the population was 541.
Clifton is located in the East side of the county, between the cities of Spartanburg and Cowpens.
According to the United States Census Bureau, the CDP has a total land area of 1.073 square miles (2.946 km) and a total water area of 0.065 square mile (0.168 km).
It is in the Spartanburg School District 3.