Clearwater River Dene Band 222 is an Indian reserve of the Clearwater River Dene Nation in Saskatchewan. It is south-west of La Loche. In the 2016 Canadian Census, it recorded a population of 822 living in 188 of its 218 total private dwellings. In the same year, its Community Well-Being index was calculated at 49 of 100, compared to 58.4 for the average First Nations community and 77.5 for the average non-Indigenous community.