Claude Spanghero (born 5 June 1948) is a former French rugby union footballer. He played at number 8 and as a lock.
He was part of the French side which won the Five Nations in 1973. He played for France 22 times, including 7 with his brother Walter Spanghero. He famously had a very stormy relationship with his older brother, who was also an international rugby player for France.