The Clark Royster House is a historic home located at Clarksville, Mecklenburg County, Virginia. It was built about 1840, and is a two-story, single-pile Federal-style brick dwelling. Also on the property are the contributing site of a combined kitchen and slave quarters and an original 65-foot-deep rock well. It was the former home of Clark Royster, founder of the town of Clarksville.
It was listed on the National Register of Historic Places in 1996.