cis-Diamminediiodoplatinum(II) is a coordination complex of platinum(II) with the formula . It is a red solid. Its structure has been confirmed by X-ray crystallography. It is the usual precursor to a popular anticancer drug cisplatin, cis-.
Its synthesis entails the reaction of ammonia with potassium tetraiodoplatinate, generated in situ via the reaction of potassium tetrachloroplatinate with potassium iodide:
In this conversion, the addition of the second ammonia ligand is governed by the trans effect.
A variety of related alkylamine complexes can be prepared similarly.
Of commercial interest, cis- reacts with aqueous silver nitrate to give the diaquo complex, which subsequently can be converted to cisplatin:
cis- reacts with perchloric acid to undergo deamination, giving the dimeric iodo-bridged complex:
This dimeric complex can then be aminated:
Oxidative addition of iodine to cis- gives the trans Pt(IV) derivative: