The Church of St. John Nepomucene is a Roman Catholic parish located on East 66th Street and 1st Avenue in Manhattan, New York City. The founders of the church were recent immigrants from Slovakia, who began meeting in St. Brigid's Parish at 8th Street and Avenue B in about 1891 and established the Society of St. Matthew to organize their own parish.
The parish was established in 1895 from within St. Elizabeth of Hungary parish, which was centered on its church on 83rd Street. The church, school and rectory were built for $300,000.