Church of SS Mary and Ambrose, Edgbaston is a Grade II listed parish church in the Church of England in Birmingham.
The site for the church was given by Augustus Gough-Calthorpe, 6th Baron Calthorpe. The church cost ã8,000 with the parishioners contributing ã2,000 and the Misses Stokes of the Hawthorns, Edgbaston, the balance. The church was consecrated by the Bishop of Worcester Rt. Revd. John Perone on 28 September 1898.
The church was built between 1897 and 1898 by J. A. Chatwin. It was a daughter parish to St Bartholomew's Church, Edgbaston.
The first organ in the church was built by J. W. Walker & Sons Ltd in 1898. A specification of the organ can be found on the National Pipe Organ Register.