Chromosome 3 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 3 spans more than 201 million base pairs (the building material of DNA) and represents about 6.5 percent of the total DNA in cells.
Genes
Number of genes
The following are some of the gene count estimates of human chromosome 3. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.
List of genes
The following is a partial list of genes on human chromosome 3. For complete list, see the link in the infobox on the right.
p-arm
Partial list of the genes located on p-arm (short arm) of human chromosome 3:
q-arm
Partial list of the genes located on q-arm (long arm) of human chromosome 3:
Diseases and disorders
The following diseases and disorders are some of those related to genes on chromosome 3:
- 3-Methylcrotonyl-CoA carboxylase deficiency
- 3q29 microdeletion syndrome
- Acute myeloid leukemia (AML)
- Alkaptonuria
- Arrhythmogenic right ventricular dysplasia
- Atransferrinemia
- Autism
- Autosomal dominant optic atrophy
- ADOA plus syndrome
- Biotinidase deficiency
- Blepharophimosis, epicanthus inversus and ptosis type 1
- Breast/colon/lung/pancreatic cancer
- Brugada syndrome
- Castillo fever
- Carnitine-acylcarnitine translocase deficiency
- Cataracts
- Cerebral cavernous malformation
- CharcotâÂÂMarieâÂÂTooth disease, type 2
- CharcotâÂÂMarieâÂÂTooth disease
- Chromosome 3q duplication syndrome
- Coproporphyria
- A location on human chromosome 3 is associated with respiratory failure and possibly with increased severity in COVID-19
- DandyâÂÂWalker syndrome
- Deafness
- Diabetes
- Dystrophic epidermolysis bullosa
- Endplate acetylcholinesterase deficiency
- Essential tremors
- Ectrodactyly, Case 4
- Glaucoma, primary open angle
- Glycogen storage disease
- HaileyâÂÂHailey disease
- Harderoporphyrinuria
- Heart block, progressive/nonprogressive
- Hereditary coproporphyria
- Hereditary nonpolyposis colorectal cancer
- HIV infection, susceptibility/resistance to
- Hypobetalipoproteinemia, familial
- Hypothermia
- Leukoencephalopathy with vanishing white matter
- Long QT syndrome
- Lymphomas
- Malignant hyperthermia susceptibility
- Metaphyseal chondrodysplasia, Murk Jansen type
- Microcoria
- Möbius syndrome
- Moyamoya disease
- Mucopolysaccharidosis
- MuirâÂÂTorre family cancer syndrome
- Myotonic dystrophy
- Neuropathy, hereditary motor and sensory, Okinawa type
- Night blindness
- Nonsyndromic deafness
- Ovarian cancer
- Porphyria
- Propionic acidemia
- Protein S deficiency
- Pseudocholinesterase deficiency
- Pseudo-Zellweger syndrome
- Retinitis pigmentosa
- RomanoâÂÂWard syndrome
- Seckel syndrome
- Sensenbrenner syndrome
- Septo-optic dysplasia
- Short stature
- Spinocerebellar ataxia
- Sucrose intolerance
- T-cell leukemia translocation altered gene
- Usher syndrome
- von HippelâÂÂLindau syndrome
- Waardenburg syndrome
- Xeroderma pigmentosum, complementation group c
Cytogenetic band
See also
References
External links