Chlorite dismutase, also known as Chlorite O<sub>2</sub>-lyase (), is an enzyme that catalyzes the chemical reaction
Reactions that generate oxygen molecules are exceedingly rare in biology, except in photosynthesis, and they are difficult to mimic synthetically. Perchlorate-respiring bacteria enzymatically detoxify chlorite (), the end product of the perchlorate () respiratory pathway, by converting it to dioxygen () and chloride (). Chlorite dismutase is a hemoprotein, but it bears no structural or sequence relationships with known peroxidases or other heme proteins, and is part of a large family of proteins with more than one biochemical function.