Chiusano d'Asti is a comune (municipality) in the Province of Asti in the Italian region Piedmont, located about southeast of Turin and about northwest of Asti. As of 31 December 2004, it had a population of 236 and an area of .
Chiusano d'Asti borders the following municipalities: Asti, Camerano Casasco, Cinaglio, Cossombrato, Montechiaro d'Asti, and Settime.