Chile Route 27 (Ruta 27 CH) is a main road in the northern portion of Chile. It runs from San Pedro de Atacama to Paso de Jama. A short road off Route 27 heads north to Portezuelo del Cajón. Another adjacent road leads to Llano de Chajnantor Observatory, reaching maximum altitude of . The Chile Route 27 reaches an altitude according to OpenStreetMap of at at a road distance of west of the border, making it one of the highest highways in South America.
The sections Salar de Pujsa and Salar de Tara-Salar de Aguas Calientes of Los Flamencos National Reserve can be accessed by this road.