The sixth season of Chicago Med, an American medical drama television series with executive producer Dick Wolf, and producers Michael Brandt, Derek Haas, Peter Jankowski, Andrew Schneider and Diane Frolov, was ordered on February 27, 2020. The season premiered on November 11, 2020. Storylines reflected the impact of the COVID-19 virus and marked the final main series appearance of ED nurse April Sexton (portrayed by Yaya DaCosta).
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After shutting down in early March due to COVID-19, production on the new season picked up on Sept. 22. NBC revealed on September 29, 2020, that the series took a two-week hiatus after a crew member tested positive for COVID-19. The positive result was discovered during rapid testing and the unnamed individual was immediately sent home. The temporary shutdown did not affect Med's Season 6 premiere or the production schedules for Chicago Fire and Chicago P.D..
On September 22, 2020, Tehmina Sunny has been tapped for a multi-episode arc. On May 12, 2021, it was announced that longtime cast members Yaya DaCosta and Torrey DeVitto would depart the series at the end of the sixth season opting not to renew their contracts and instead pursue new work opportunities. DeVitto appeared in the season 7 premiere to wrap up her character's storyline.