Mound City station, also known as the Mound City Museum, is a historic train station located at Mound City, Holt County, Missouri. It was built in 1921 by the Chicago, Burlington and Quincy Railroad, and is a simple one-story, hollow tile and red brick building measuring 100 feet by 25 feet. It sits on a concrete foundation and has a gable roof. It houses a local history museum.
It was listed on the National Register of Historic Places in 1978 as the Chicago, Burlington and Quincy Depot.