The Cherokee IOOF Lodge No. 219 is an Odd Fellows building in Cherokee, Oklahoma that was built in 1931. It has served historically as a clubhouse, as a restaurant, as a mortuary, and as a business. It was listed in the National Register of Historic Places in 1984.
It is one of four historic, surviving Odd Fellows buildings in Alfalfa County that were subject of a 1983 study. The others are the Aline IOOF Lodge No. 263 in Aline and the Carmen IOOF Home and Carmen IOOF Lodge No. 84 in Carmen.