Cheiramiona simplicitarsis is a species of spider in the family Cheiracanthiidae. It is a South African endemic originally described from Kamaggas in Northern Cape.
The species is known from three provinces at elevations from 576-1341 m above sea level.
This species is a free-living plant dweller recorded from the Succulent Karoo, Nama Karoo and Savanna biomes.
Due to its wide geographical range, the species is listed as Least Concern. It is protected in Lhuvhondo Nature Reserve, Anysberg Nature Reserve and Tswalu Game Reserve.