The Charolais-Brionnais region () is located in the southwest of the French department of the Saône-et-Loire in Burgundy. Created in 2004, the region comprises a population of 90,000 inhabitants across 129 municipalities.
The Charolais-Brionnais region is home to the renowned Charolais cattle and is an applicant for UNESCO status as a World Heritage Site to preserve, consolidate and transmit this resource.
The Loire River, flanked by its adjoining canals, flows on the western edge of Charolais-Brionnais. The EuroVelo long-distance cycling route EV6, also named the Rivers Route, leaves the Loire at Digoin for the Canal du Centre, where it starts its way through the Charolais.
The Charolais-Brionnais was awarded with two food certifications of the European Union (protected designation of origin; ) for AOP Charolles Beef and AOP Charolais Goat Cheese.