Charlotte Vandermeersch (born 11 November 1983) is a Belgian actress and screenwriter.
Vandermeersch was born in Oudenaarde and grew up in , a village in Kruishoutem. After graduating from high school, she studied drama at the in Antwerp. From 2012 to 2020, she was a member of the theater company . She later co-wrote and directed the film The Eight Mountains, which won the Jury Prize at the 2022 Cannes Film Festival. In 2025, she was named Master of the Ostend Film Festival, a title awarded annually to a Flemish film professional.
Vandermeersch is in a long-term relationship with director Felix van Groeningen. They have a son, Rufus.