Charlie Creek is a stream in Hardee County and Polk County, Florida, in the United States.
One etymology is that the stream was named for an otherwise unknown Seminole chief Charlie Apopka, Another etymology states that "Charlie Apopka" is likely a corruption of chalo apopka, meaning "trout (or bass) eating place". It was known as Charlie Apopka Creek or Big Charlie Apopka Creek in the 19th century.
Charlie Creek is an important tributary of the Peace River, discharging a mean of per day into the river. It is long with a basin in area in Desoto, Hardee, Highlands, and Polk counties. Average elevation of the stream is less than above sea level, ranging from above sea level at the source to at the juncture with the Peace River.