Chamazulene is an aromatic chemical compound with the molecular formula C<sub>14</sub>H<sub>16</sub> found in a variety of plants including in chamomile (Matricaria chamomilla), wormwood (Artemisia absinthium), and yarrow (Achillea millefolium). It is a blue-violet derivative of azulene formed from sesquiterpene matricin after the loss of acetate, water and carbon dioxide during the steam distillation of chamomile blossoms. Oral ingestion of matricin results in chamazulene being found in blood plasma and artificial gastric fluid is able to convert matricin to chamazulene.
Chamazulene has anti-inflammatory properties in vivo and inhibits the CYP1A2 enzyme, but not CYP1A1.