Cham Khalaf-e Isa District () is in Hendijan County, Khuzestan province, Iran. Its capital is the city of Zahreh.
At the time of the 2006 National Census, the district's population was 7,217 in 1,424 households. The following census in 2011 counted 6,934 people in 1,712 households. The 2016 census measured the population of the district as 6,650 inhabitants in 1,856 households.