Cernusco Lombardone (Brianzöö: ) is a comune (municipality) in the Province of Lecco in the Italian region Lombardy, located about northeast of Milan and about south of Lecco. As of 31 December 2007, it had a population of 3,863 and an area of .
Cernusco Lombardone borders the following municipalities: Merate, Montevecchia, Osnago. It is served by Cernusco-Merate railway station.