Centre-Ouest Department was a department of Ivory Coast between 1963 and 1969. It was established in 1963 as a split-off from Sud-Ouest Department. During Centre-Ouest Department's existence, departments were the first-level administrative subdivisions of Ivory Coast.
Using current boundaries as a reference, the territory of Centre-Ouest Department was composed of Haut-Sassandra Region, Gôh Region, and Nawa Region.
In 1969, Centre-Ouest Department and the other five existing departments of the country were abolished and replaced with 24 new departments. The territory of Centre-Ouest Department became the new departments of Daloa, Gagnoa, and Sassandra.