The Central Missouri Activities Conference, or CMAC, is a high school athletic conference comprising large-size high schools located in Mid-Missouri. The conference members are located in Boone, Camden, Cole, and Pettis counties.
Founded in 2020, the Central Missouri Activities Conference consists of seven high schools at its founding. The conference consists of Class 5 and Class 6 schools (in boys' basketball), the two largest classes in Missouri. Camdenton High School became a member at the beginning of the 2024-2025 Academic year after the demise of the Ozark Conference.