The Central District of Tuyserkan County () is in Hamadan province, Iran. Its capital is the city of Tuyserkan.
At the time of the 2006 National Census, the district's population was 88,251 in 24,004 households. The following census in 2011 counted 84,214 people in 26,192 households. The 2016 census measured the population of the district as 84,742 inhabitants in 28,326 households.