The Central District of Osku County () is in East Azerbaijan province, Iran. Its capital is the city of Osku.
The village of Sahand was converted to a city in 2008.
At the time of the 2006 census, the district's population was 56,253 in 15,908 households. The following census in 2011 counted 69,116 people in 21,041 households. The 2016 census measured the population of the district as 127,452 inhabitants in 40,586 households.