The Central District of Khusf County () is in South Khorasan province, Iran. Its capital is the city of Khusf.
In 2012, Khusf District was separated from Birjand County in the establishment of Khusf County, which was divided into two districts and five rural districts, with Khusf as its capital. After establishment of the county, the village of Mohammadiyeh was elevated to city status as Mohammadshahr.
At the time of the 2016 National Census, the district's population was 18,248 inhabitants in 4,325 households.