The Central District of Andika County () is in Khuzestan province, Iran. Its capital is the city of Qaleh-ye Khvajeh.
After the 2006 National Census, Andika District was separated from Masjed Soleyman County in the establishment of Andika County, which was divided into three districts of two districts each, with Qaleh-ye Khvajeh as its capital and only city at the time.
At the time of the 2011 census, the district's population was 17,782 people in 3,674 households. The 2016 census measured the population of the district as 17,196 inhabitants in 4,270 households.