Cayuga is an unincorporated community in Hinds County, in the U.S. state of Mississippi.
Cayuga was a point on the Natchez Trace, the stop after Rocky Springs when heading northeast toward Nashville. It lay within the Choctaw Nation, just outside the Anglo-Spanish colonial Natchez District. The community is named after Cayuga Lake, in New York. Cayuga was once home to two churches. A post office called Cayuga was established in 1829, and remained in operation until 1906. A variant name was "Cayuga Plantation".