Castrofilippo (Sicilian: Castrufilippu) is a comune (municipality) in the Province of Agrigento in the Italian region Sicily, located about southeast of Palermo and about east of Agrigento. As of 31 December 2004, it had a population of 3,170 and an area of .
Castrofilippo borders the following municipalities: Canicattì, Favara, Naro, Racalmuto.