Castelvetro di Modena (Modenese: ) is a town and comune (municipality) in the Province of Modena in the Italian region Emilia-Romagna, located about west of Bologna and about south of Modena.
The municipality borders Castelnuovo Rangone, Formigine, Maranello, Marano sul Panaro, Spilamberto, Serramazzoni and Vignola. It counts the hamlets (frazioni) of Ca' di Sola, Ca' Gatti, Ca' Montanari, Casa Re, Levizzano Rangone, Madonna di Puianello, Sant'Eusebio, Settecani and Solignano Nuovo.