Casalserugo is a comune (municipality) in the Province of Padua in the Italian region Veneto, located about southwest of Venice and about southeast of Padua. As of 31 December 2004, it had a population of 5,525 and an area of .
Casalserugo borders the following municipalities: Albignasego, Bovolenta, Cartura, Maseràdi Padova, Polverara, Ponte San Nicolò.
Casalserugo is twinned with: