Casaletto Vaprio () is a comune (municipality) in the Province of Cremona in the Italian region Lombardy, located about east of Milan and about northwest of Cremona. Notable natives include the composer Stefano Pavesi.
Casaletto Vaprio borders the following municipalities: Campagnola Cremasca, Capralba, Cremosano, Quintano, Trescore Cremasco.
Casaletto Vaprio has a railway station on the TreviglioâÂÂCremona line.