The Carlisle Rock Island Depot is a historic railroad station at Main and Court Streets in Carlisle, Arkansas.
The Carlisle Rock Island Depot is a -story masonry and frame structure, finished in brick with half-timbered stucco. A passenger station, it was organized with a central service area for ticketing and telegrapher's bay, with waiting rooms on either side, one for whites, and one for African-Americans. The station was built about 1920 by the Rock Island Railroad; it is a prominent local example of Tudor Revival style, and is historically significant for its role in the growth of the city of Carlisle. The station played a significant role in Arkansas history when publicity campaigns were run in Illinois and Iowa encouraging people to move to Arkansas during the boom years of 1905-1920.
The building was listed on the National Register of Historic Places in 1990.