Cannabipiperidiethanone (CPE or 1-(N-methylpiperidin-2-ylmethyl)-3-(2-methoxyphenylacetyl)indole) is a synthetic cannabinoid that has been found to be an ingredient of "herbal smoking blends" sold in Japan.
The drug's binding affinity was measured at the CB<sub>1</sub> and CB<sub>2</sub> receptors and it was found to have an IC<sub>50</sub> of 591 nM at CB<sub>1</sub> and 968 nM at CB<sub>2</sub>, making it 2.3 times and 9.4 times weaker than JWH-250 at these two targets respectively.
In the United States, CB<sub>1</sub> receptor agonists of the 3-phenylacetylindole class such as cannabipiperidiethanone are Schedule I Controlled Substances.