Cane Creek is a stream in Cape Girardeau County, Missouri. It is a tributary of Byrd Creek.
The stream headwaters arise at along the west side of Fruitland. The stream flows to the southwest passing under I-55 and then Missouri Route 34 west of Jackson to its confluence with Byrd Creek 2.5 miles southeast of Burfordville at .
Cane Creek was lined with cane, hence the name.