Calligrapha serpentina, the globemallow leaf beetle, is a species of leaf beetle in the family Chrysomelidae. It is found in Mexico and the United States.
In 2021, several important taxonomic changes were made: the species Calligrapha mexicana was revalidated, reversing a long-held synonymy with C. serpentina, and the variety Calligrapha serpetina var. discrepans was upgraded in status to species as Calligrapha discrepans.