Calico Creek is a rural locality in the Gympie Region, Queensland, Australia. In the , Calico Creek had a population of 185 people.
Mary Valley Road (State Route 51) forms the north-eastern boundary. Calico Creek, a tributary of the Mary River, rises in the south of the locality and flows through to the north. Almost all of the southern boundary is the northern extent of Amamoor National Park.
Calico Creek State School opened on 8 July 1936 and closed on 31 August 1970. The school was at 8 Robinson Road (south-east corner of Calico Creek Road, ).
In the , Calico Creek had a population of 156 people.
In the , Calico Creek had a population of 185 people.
There are no schools in Calico Creek. The nearest government primary schools are Dagun State School in neighbouring Dagun to the south-east and Jones Hill State School in Jones Hill to the north. The nearest government secondary school is Gympie State High School in Gympie to the north.