Calamandrana is a comune (municipality) in the Province of Asti in the Italian region Piedmont, located about southeast of Turin and about southeast of Asti.
Calamandrana borders the following municipalities: Canelli, Cassinasco, Castel Boglione, Nizza Monferrato, Rocchetta Palafea, and San Marzano Oliveto.
Calamandrana is twinned with: