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CP-132,484

CP-132,484, also known as 4,5-dihydropyrano-1-methyltryptamine (4,5-DHP-1-Me-T), is a tryptamine derivative which acts as a potent and selective agonist for the 5-HT<sub>2</sub> family of serotonin receptors. It has reasonable selectivity for 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> subtypes over 5-HT<sub>2B</sub>, but is only slightly selective for 5-HT<sub>2A</sub> over 5-HT<sub>2C</sub>. This compound and several related analogues have been shown to have ocular hypotensive activity in animal models, suggesting they may be useful for the treatment of glaucoma.

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