COUP-TF1 (<u>COUP</u> <u>T</u>ranscription <u>F</u>actor <u>1</u>) also known as NR2F1 (<u>N</u>uclear <u>R</u>eceptor subfamily <u>2</u>, group <u>F</u>, member <u>1</u>) is a protein that in humans is encoded by the NR2F1 gene. This protein is a member of nuclear hormone receptor family of steroid hormone receptors.
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.
COUP-TFI has been shown to interact with:
Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome.