CDC5L

Cell division cycle 5-like protein is a protein that in humans is encoded by the CDC5L gene.

Function

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G₂/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G₂/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.

Interactions

CDC5L has been shown to interact with:

• ASF/SF2,
• BZW1,
• CWC15,
• DNA-PKcs,
• DYNC1H1,
• GCN1L1,
• HSPA8,
• ILF2,
• PLRG1,
• PPM1D,
• PPP1CA,
• PRPF19,
• RBMX and
• RPL12,
• RPL13,
• RPS16,
• RPS25,
• SF3A1,
• SF3B1,
• SF3B2,
• SF3B4,
• SFPQ,
• SRSF2,
• SNRPA1,
• SNRPD3,
• SRRM1,
• Small nuclear ribonucleoprotein D1,
• Small nuclear ribonucleoprotein D2,
• Small nuclear ribonucleoprotein polypeptide A,
• TOP2A, and
• TTF2.

See also

• G2/M checkpoint

References

Further reading

External links