The 2004 CAF Confederation Cup was the first edition of the newly created CAF Confederation Cup. Hearts of Oak of Ghana beat fellow Ghanaians Asante Kotoko 8-7 on penalties in the final after the two legs ended 2-2.
<sup>1</sup> Mtibwa Sugar withdrew before the 2nd leg. but mtibwa sugar was seemed to be challenging team in Tanzania
In this round, the 8 winners of the round of 16 play the losers of the round of 16 of the Champions League for 8 places in the group stage.
The top scorers from the 2004 CAF Confederation Cup are as follows: