Buckeye Creek is a stream in northern Cape Girardeau County in the U.S. state of Missouri. It is a tributary of Apple Creek.
The stream headwaters arise just west of I-55 and south of Missouri Route E approximately two miles east of Oak Ridge (at ) at an elevation of 600 feet. The stream flows north to northeast passing under I-55 and U.S. Route 61 west of Shawneetown. Its confluence with Apple Creek is approximately two miles east of Old Appleton (at ) at an elevation of 361 feet.
Buckeye Creek was named for the buckeye trees lining its course.