Brushy Creek is a stream in southeastern Ste. Genevieve County in the U.S. state of Missouri. It is a tributary of Saline Creek. The headwaters of Brushy Creek are within the Mark Twain National Forest at and the stream flows northeast to its confluence with Saline Creek about 1.5 miles southwest of the community of Minnith at at an elevation of 440 feet.
Brushy Creek was so named on account of brush along its course.